Substituted N-methylene derivatives of thienamycin sulfoxide and

Details Substituted N-methylene derivatives of thienamycin sulfoxide and Substituted N-methylene derivatives of thienamycin sulfoxide and

1977-09-15

1980-11-04

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602452T, 424267, 424269, 424270, 424272, 424273R, 424274, 542416, 544144, 544333, 546 23, 546200, 546272, A61K 3140, C07D48704, A61K 3144

Patent

active

042320305

ABSTRACT:
Disclosed are substituted N-methylene derivatives of thienamycin sulfoxide (I, n=1) and sulfone (I, n=2) which may be represented by the following structural formula: ##STR1## wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR.sup.1 R.sup.2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R.sup.1 and R.sup.2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3862181 (1975-01-01), Davis et al.
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4000129 (1976-12-01), Verwey et al.
patent: 4000161 (1976-12-01), Geogilman et al.
patent: 4022773 (1977-05-01), Ishimaru
patent: 4150145 (1979-04-01), Christensen et al.
patent: 4172144 (1979-10-01), Bouffard et al.
Derwent Abstract; 26432B; (4/4/79).

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