Treatment of psychic disorders and inflammation with fused isoqu

Details Treatment of psychic disorders and inflammation with fused isoqu Treatment of psychic disorders and inflammation with fused isoqu

1979-05-22

1980-11-04

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424857, 424250, 424258, 544 586, 544 60, 544176, 544361, 546 82, 546 83, A61K 3154, A61K 3147, C07D47104, C07D51304

Patent

active

042320178

ABSTRACT:
New tricyclic ortho-fused heterocyclic compounds of formula ##STR1## wherein A is the group ##STR2## or the group ##STR3## in which R represents hydrogen, (C.sub.1-4)alkyl, phenyl or tolyl and R.sub.1 and may be (C.sub.1-4)alkyl, phenyl or tolyl, R.sub.2 is selected from (C.sub.1-4)alkyl, (C.sub.2-4)alkanoylmethyl, carbo(C.sub.1-3)alkoxymethyl, hydroxy(C.sub.2-4)alkyl, halo(C.sub.2-4)alkyl and a group ##STR4## wherein R.sub.3 is an alkylene group from 2 to 4 carbon atoms and R.sub.4 and R.sub.5 independently represent hydrogen or (C.sub.1-4)alkyl or, taken together with the nitrogen atom, a fully hydrogenated 5 or 6 membered heterocyclic radical which may contain a further heteroatom selected from O, N and S and be optionally substituted by a (C.sub.1-4)alkyl or phenyl group, or R.sub.2 may represent, nil the dotted lines x and y may represent nil or additional bonds; with the proviso that, when the symbol R.sub.2 linked to the oxygen atom is different from nil, x is an additional bond and y and the other symbol R.sub.2 represent nil; with the further proviso that, when the symbol R.sub.2 linked to the nitrogen atom is different from nil, y is an additional bond and x and the other symbol R.sub.2 represent nil; and salts therewith of pharmaceutically acceptable acids. The compounds possess antiinflammatory, CNS-depressent and anti-anxiety utility.

REFERENCES:
patent: 3630745 (1971-12-01), Beavers et al.
patent: 3816429 (1974-06-01), Finch
patent: 3890324 (1975-06-01), Katner
patent: 4113731 (1978-09-01), Winters et al.
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 298, 331 and 343.
Winters, G., et al., Tett. Lett., #44, 3877-3878 (1975).

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