Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1997-03-06
1998-07-21
Brouillette, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424488, 6048921, A61K 924
Patent
active
057832137
ABSTRACT:
The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
Eckenhoff James B.
Merrill Sonya
Osborne James L.
Rivera David L.
Wright Jeremy C.
ALZA Corporation
Brouillette D. Gabrielle
Dillahunty Mary Ann
Stone Steve F.
LandOfFree
Osmotic membrane and delivery device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Osmotic membrane and delivery device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Osmotic membrane and delivery device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1644496