Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vi

Details Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vi Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vi

1998-12-14

2000-11-07

Badio, Barbara

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C07C40100

Patent

active

06143910&

ABSTRACT:
1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.

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