Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-05-06
2000-11-07
Duffy, Patricia A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 53038826, 5303891, C07K 1600, C12P 2108
Patent
active
061438758
ABSTRACT:
The present invention relates to novel DNases .alpha., .beta. and .gamma. capable of selectively cleaving the linker sites of chromatin DNA. The present invention also relates to novel DNase .gamma. involved in fragmentation of chromatin DNA in apoptosis. The present invention further relates to amino acid sequence of DNase .gamma., DNA encoding said enzyme, nucleotide sequence of said DNA, recombinant vector containing said DNA, transformant containing said recombinant vector, production method of DNase .gamma. comprising culture of said transformant, and antibody having affinity for said DNase .gamma., precursor thereof and the amino acid sequence of fragments thereof. The DNase .gamma. of the present invention takes part in the control system of apoptosis, and effectively contributes to the development of medications for the prevention, treatment and diagnosis of apoptosis-inhibitory or promotive diseases such as cancer, autoimmune diseases and viral infections. In addition, the DNases .alpha. and .beta. of the present invention increase upon viral infection to cleave viral DNA, and are useful for the development of therapeutic agents for viral infections.
REFERENCES:
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