Benzopyranone and quinolone inhibitors of ras farnesyl transfera

Details Benzopyranone and quinolone inhibitors of ras farnesyl transfera Benzopyranone and quinolone inhibitors of ras farnesyl transfera

2000-01-20

2000-11-07

Seaman, D. Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, 546157, 5483114, A61K 3147, A61K 31415, C07D21516, C07D23302

Patent

active

061437662

ABSTRACT:
The present invention provides ras farnesyl transferase inhibiting compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.

REFERENCES:
patent: 4690932 (1987-09-01), Kojima
patent: 5073563 (1991-12-01), Frickel
patent: 5227392 (1993-07-01), Frickel
Abyshev, A. Z., et al., "Synthesis and Biological Activity of Derivatives of Benzopyran-2-One", Pharm. Chem. J., vol. 27, No. 11, 1993, pp. 766-770.
Abyshev, A. Z., et al., "Synthesis and Biological Activity of Benzopyran-2-one Derivatives", Russia Khim-Farm. Zh., vol. 27, No. 11, 1993, pp. 34-38.

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