Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-03-06
2000-11-07
Horlick, Kenneth R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 5, 435 911, 435 912, 536 243, 536 266, C12Q 168, C12Q 170, C12P 1934
Patent
active
061434973
ABSTRACT:
A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
REFERENCES:
patent: 4182654 (1980-01-01), Royer
patent: 4315074 (1982-02-01), Royer
patent: 4587044 (1986-05-01), Miller et al.
patent: 4631211 (1986-12-01), Houghten
patent: 4671941 (1987-06-01), Niina et al.
patent: 4701304 (1987-10-01), Horn et al.
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4755558 (1988-07-01), Kalbag
patent: 4794150 (1988-12-01), Steel
patent: 4818681 (1989-04-01), Dattagupta
patent: 4833092 (1989-05-01), Geysen
patent: 4855225 (1989-08-01), Fung et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5264563 (1993-11-01), Huse
patent: 5708153 (1998-01-01), Dower et al.
Amato, 1992, Science, 257:330-331 Speeding up a chemical game of chance.
Hodgson, 1992, Bio/Technology 10:973-974 Receptor screening and the search for new pharmaceuticals.
Mathur et al., 1980, Polymers as Aids in Organic Chemistry, Academic Press, New York, Ch. 9-12:138-197.
Needels et al., 1993, Proc. Natl. Acad. Sci, USA, 90:10700-10704 Generation and screening of an oligonucleotide-encoded sythetic peptide library.
Advances in Analytical Chemistry and Instrumentation, Charles N. Reilley, Ed., John Wiley & Sons, Inc., 1964, pp. 56-59.
Arnold et al., Mar. 15, 1991, Optics Letters 16(6):420-422 Room-temperature microparticle-based persistent spectral hole burning memory.
Baldwin et al., 1990, Tetrahedron 46(19):6879-6884 New photolabile phosphate protecting groups.
Barr et al., 1986, BioTechniques 4(5):428-432, 7-Deaza-2'-deoxyguanosine-5'-triphosphate: Enchanced resolution in M13 dideoxy sequencing.
Bashkin et al., 1991, J. Org. Chem. 56:3168-3176 Synthesis and characterization of oligonucleotide peptides.
Brenner et al., 1992, Proc. Natl. Acad. Sci. USA 89:5381-5383 Encoded combinatorial chemistry.
Cwirla et al., 1990, Proc. Natl. Acad. Sci. USA 87:6378-6382 Peptides on phage: A vast library of peptides for indentifying ligands.
Eritja et al., 1991, Tetrahedron 47(24):4113-4120, Synthesis of defined peptide-oligonucleotide hybrids containing a nuclear transport signal sequence.
Fodor et al., 1991, Science 251:767-773 Light-directed, spatially addressable parallel chemical synthesis.
Frank and Doring, 1988, Tetrahedron 44(19):6031-6040 Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports.
Frank et al., 1983, Nuc. Acids. Res. 11(13):4365-4377 A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: Segmental solid supports.
Frank et al., 1990, Peptides (Giralt & Andreu, eds., ESCOM Science Pub.), pp. 151-152 Facile and rapid `spot-synthesis` of large numbers of peptides on membrane sheets.
Furka et al., Jul. 10-15, 1988, 14th Intl. Congress of Biochemistry, Prague, Czechoslovakia, Abstract No. FR:013 Proteins and nucleic acids in threee dimensions: Cornucopia of peptides by synthesis.
Furka et al., Aug. 15-19, 1988, Xth Intl. Symp. on Medicinal Chem., Budapest, Hungary, Abstract No. P-168, p. 268 More peptides by less labour.
Furka et al., 1991, Int. J. Peptide Protein Res., 37:487-493 General method for rapid synthesis of multicomponent peptide mixtures.
Geysen et al., 1987, J. Immunol. Meth., 102:259-274 Strategies for epitope analysis using peptide synthesis.
Geysen et al., 1984, Proc. Natl. Acad. Sci. USA, 81:3998-4002 Use of peptide synthesis to probe viral antigens for epitopes to a resoution of a single amino acid.
Haralambidis et al., 1990, Nuc. Acids Res. 18(3):493-505 The synthesis of polyamide-oligonucleotide conjugate molecules.
Hayakawa et al., 1990, J. Am. Chem. Soc. 112:1691-1696 The allylic protection method in solid-phase oligonecleotide synthesis: An efficient preparation of solid-anchored DNA Oligomers.
Houghten et al., 1991, Nature 354:84-86 Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.
Houghten, 1985, Proc. Natl. Acad. Sci. USA 82:5131-5135 General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids.
Juby et al., 1991, Tetrahedron Letters 32(7):879-882 Facile preparation of 3' oligonucleotide-peptide conjugates.
Kaiser et al., 1989, Science 243:187-192 Peptide and protein synthesis by segment synthesis-condensation.
Kerr et al., 1993, J. Am Chem Soc., 115:2529-2531 Encoded combinatorial peptide libraries containing non-natural amino acids.
Lam et al., 1991, 12th Amer. Pep. Symp., Abstract LW3 Rapid selection and structure determination of acceptor binding ligands from a large synthetic peptide library.
Lam et al., 1991, Nature 354:82-84 A new type of synthetic peptide library for indentifying ligand-binding activity.
Nikolaiev et al., 1993, Peptide Research, 6(3):161-170 Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid phase supports.
Ohlmeyer et al., 1993, Proc. Natl. Acad. Sci. USA, 90:10922-10926 Complex synthetic chemical libraries indexed with molecular tags.
Tjoeng et al., 1990, Int. J. Pept. Protein Res. 35:141-146 Multiple peptide synthesis using a single support (MPS3).
Van der Zee et al., 1989, Eur. J. Immunol. 19:43-48 Efficient mapping and characterization of a T cell epitope by the simultaneous synthesis of multiple peptides.
Barrett Ronald W.
Dower William J.
Gallop Mark A.
Affymax Technologies N.V.
Horlick Kenneth R.
Kaster Kevin R.
Stevens Lauren L.
Tung J.
LandOfFree
Method of synthesizing diverse collections of oligomers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of synthesizing diverse collections of oligomers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of synthesizing diverse collections of oligomers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1639177