Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-03-17
1988-02-02
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 95, 514 96, 514443, 549 6, 549 58, 549 75, 549 77, A61K 3138, C07D33300, C07D33356, C07D33312
Patent
active
047229330
ABSTRACT:
The invention provides compounds represented by the general formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R.sub.5 is selected from the group consisting of alkyl and aromatic residues; n is 2 or 3; and R.sub.1 is selected from the group consisting ##STR3## wherein R.sub.6 is selected from the group consisting of halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl, comprising from 1 to 12 carbon atoms and wherein said hetero-atoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus; R.sub.7 is R.sub.6 or H and m equals 1, 2 or 3; with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is H, that at least one of R.sub.2, R.sub.3 and R.sub.4 is not H and that R.sub.2 and R.sub.4 are not both OA; and pharmaceutically-acceptable salts thereof. The compounds are dopamine receptor agonists and useful for the treatment of glaucoma in mammals.
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Hacksell et al., Journal of Medicinal Chemistry, vol. 22, No. 12 at pp. 1469-1475, (corresponding to European Appln. 041,488).
Beaulieu et al., European Journal of Pharmacology, 105, (1984), at pp. 15-21.
Baran Robert J.
Nelson Research & Development Co.
Siegel Alan
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