Process for the manufacture of enol derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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544 17, 544 22, 544 23, 544 29, 424246, C07D50108, C07D50120

Patent

active

041105338

ABSTRACT:
The invention concerns a process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolysing the enamino group in the resulting 7.beta.-acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.

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patent: 3917588 (1975-11-01), Chauvette
patent: 3944545 (1976-03-01), Chou
patent: 3974154 (1976-08-01), Nayler et al.
patent: 4008230 (1977-02-01), Koppel
patent: 4013651 (1977-03-01), Spitzer
patent: 4024152 (1977-05-01), Kukolja et al.
patent: 4048162 (1977-09-01), Kukolja et al.
patent: 4066641 (1978-01-01), Hamashima et al.

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