Product and preparation of 1H-tetrazole-5-thiol derivatives

Details Product and preparation of 1H-tetrazole-5-thiol derivatives Product and preparation of 1H-tetrazole-5-thiol derivatives

1974-10-29

1978-08-29

Waddell, Frederick E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D25704, A61K 3154

Patent

active

041103386

ABSTRACT:
The process for preparation of and the intermediate compounds such as 1H-tetrazole-5-thiol having the formula ##STR1## wherein R.sub.1 is alkyl, aminoalkyl, acylaminoalkyl, aryl, alkoxycarbonylaminoalkyl, halogen-substituted aryl or alkylamino-substituted aryl and R.sub.2 is hydrogen or arakyl, preferably benzyl. The compound is produced by reacting a substituted thiosemicarbazide with an aralkyl chloride, subjecting the resultant compound to diazotization, and reacting the resultant compound with a Friedel Crafts catalyst. Optionally, this may be further hydrolyzed when R.sub.1 is aminoalkyl and/or converted to conventional salts.

REFERENCES:
patent: 3437665 (1969-04-01), Maggiulli et al.
patent: 3557285 (1971-01-01), Enkoji et al.
patent: 3639417 (1972-02-01), Porter et al.
Berichte, 28, (1895), pp. 74-81.
Chemical Abstracts vol. 24, 2748, (1930); vol. 55, (1961), 14441-14442; vol. 63, 11544, (1965); vol. 71, 38871p (1969).

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