Cholesterol lowering compounds produced by directed biosynthesis

Details Cholesterol lowering compounds produced by directed biosynthesis Cholesterol lowering compounds produced by directed biosynthesis

1992-09-11

1994-01-11

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546270, 5483117, 548463, 549363, C07D40512, C07D40712

Patent

active

052783200

ABSTRACT:
Compounds of Structural Formula (I) ##STR1## are produced by chemical modification of directed biosynthesis products. These compounds are squalene synthetase inhibitors and thus useful as cholesterol lowering agents, antifungal agents and cancer treatment agents.

REFERENCES:
patent: 5053425 (1991-10-01), Bartizal et al.
patent: 5096923 (1992-03-01), Bergstrom et al.
Kobel and Traber, European Journal App. Microbiol. Biotechnol. 14: 237-240 (1982).
Hensens et al., J. Antibiotics, 45: 133-135 (1992).

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