Optically pure R-enantiomer of alpha,alpha-dilower alkyl-pyrroli

Details Optically pure R-enantiomer of alpha,alpha-dilower alkyl-pyrroli Optically pure R-enantiomer of alpha,alpha-dilower alkyl-pyrroli

1992-06-29

1994-01-11

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548566, C07D20709

Patent

active

052783170

ABSTRACT:
Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl]quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacterial infections therewith. Also described is a method of manufacture of the quinolones and naphthyridones as well as the starting materials, the optically pure pyrrolidine moieties for attachment at the 7-position.

REFERENCES:
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 5098912 (1992-03-01), Hayakawa et al.
Kimura et al., Int. Congress of Antimicrobial Agents and Chemotherapy, Houston, Texas (1989).
Culbertson et al., J. of Med. Chem., vol. 30, pp. 7111-1715 (1987).
Chu et al. in Advances in Drug Research--Edited by B. Testa, Academic Press, vol. 21, pp. 41 and 76-78 (1991).
Domagala et al., J. of Med. Chem., vol. 36, pp. 871-882 (1993).

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