Method of producing a polyether antibiotic from actinomadura fib

Details Method of producing a polyether antibiotic from actinomadura fib Method of producing a polyether antibiotic from actinomadura fib

1991-09-16

1994-01-11

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 74, 4352521, 435825, 435244, 435118, C12P 1718, C12P 1960, C12N 120

Patent

active

052780538

ABSTRACT:
Improved processes for producing a polyether antibiotic compound represented by A82810 comprising: (1) cultivating Actinomadura fibrosa sp. nov. NRRL 18348 or Actinomadura sp. NRRL 18880, (2) feeding acid hydrolyzed casein at a rate from about 2.50-7.50 gm/L/day, (3) feeding glucose at a rate from about 2.50-7.50 gm/L/day, and (4) feeding propionate at a rate from about 0.50-1.5 gm/L/day to the appropriate culture medium during fermentation, are provided.

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