Synthetic isohirudins with improved stability

Details Synthetic isohirudins with improved stability Synthetic isohirudins with improved stability

1993-07-29

1994-05-31

Wax, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 4351723, 4352523, 43525233, 43525421, 536 235, 935 9, 935 10, 935 28, 935 29, 935 56, 935 69, 935 73, C12N 1512, C12N 1563, C12N 1520, C12N 1581

Patent

active

053169476

ABSTRACT:
Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.

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