Process for the manufacture of 2-hydroxybenzothiazoles

Details Process for the manufacture of 2-hydroxybenzothiazoles Process for the manufacture of 2-hydroxybenzothiazoles

1981-04-29

1983-01-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424270, C07D23988

Patent

active

043704832

ABSTRACT:
A process for the manufacture of a 2-hydroxybenzothiazole compound which comprises treating a 2-aminobenzothiazole compound with an alkali metal hydroxide or alkaline earth metal hydroxide in a solvent or diluent stable to alkalis, in the absence of water or with substantial exclusion of water and cyclizing the alkali metal or alkaline earth metal salt of the ortho-mercapto-N-phenylurea compound so obtained, optionally without intermediate isolation, by treatment with an acid to give the 2-hydroxybenzothiazole compound. The process furnishes the final products with high yield and purity; waste water problems are excluded by this process.

REFERENCES:
patent: 2179987 (1939-11-01), Duzce et al.
patent: 2915525 (1959-12-01), Applegath et al.
patent: 3586690 (1971-06-01), Kuber et al.
patent: 3586691 (1971-06-01), Scott
patent: 3658835 (1972-04-01), Gates et al.
patent: 3775333 (1973-11-01), Loffelman et al.
patent: 4150027 (1978-04-01), D'Amico et al.
patent: 4252963 (1981-02-01), Papenfuhs
patent: 4293702 (1981-10-01), Umemura et al.
J. Chem. Soc. 1930, 128-135.
J. Org. Chem. 27, 477 (1962).
J. Chem. Soc. 1962, 230.
J. Chem. Soc. 1939, 470.
J. Chem. Soc. 1927, 2738.
Egypt J. Chem. 16, 335 (1973)*.
J. Chem. Soc. 1942, 304.
Chem. Ber. 12, 1128 (1879).
Chem. Ber. 13, 10 (1880).
J. Org. Chem. 30, 3618 (1965).
J. Am. Chem. Soc. JACS 71, 3349 (1949).
J. Am. Chem. Soc. JACS 74, 1081 (1952).
J. Chem. Soc. 1949, 3311.

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