Process for the preparation of mono- and bis(phosphocholine) de

Details Process for the preparation of mono- and bis(phosphocholine) de Process for the preparation of mono- and bis(phosphocholine) de

1994-04-28

1998-09-22

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 902

Patent

active

058115684

ABSTRACT:
This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be disclosed is a synthetic process for obtaining a novel class of mono- and bis(phosphocholine) derivatives which are useful as antiinfective agents. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.

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De Boer et al., 1976, "The Structure of Teichoic Acid from Bacillus subtilis var. niger WM as Determined by .sup.13 C Nuclear-Magnetic-Resonance Spectroscopy", Eur. J. Biochem. 62:1-6.
Ogawa et al., 1979, "Synthesis of the Repeating Unit of the Teichoic Acid Isolated from the Cell Wall of Bacillus subtilis VAR. niger WM", Carbohydrate Research 70:37-46.
Tsushima et al., 1982, "Syntheses and Antimicrobial Activities of Alkyl Lysophospholipids", Chem. Pharm. Bull. 30:3260-3270.
van Boeckel et al., 1983, "Synthesis of a Teichoic Acid Fragment of Bacillus subtilis Using a Modified Phosphotriester approach", Recl. Trav. Chim. Pays-Bas 102:526-537.
van Boeckel and van Boom, 1979, "Synthesis of glucosylphosphatidylglycerol via a phosphotriester intermediate", Tetrahedron Letters 37:3561-3564.

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