Substituted chromanysulfonyl (thio) ureas, processing for their

Details Substituted chromanysulfonyl (thio) ureas, processing for their Substituted chromanysulfonyl (thio) ureas, processing for their

1996-12-04

1998-09-22

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514309, 514320, 514414, 514456, 540524, 546141, 546196, 548472, 548525, 549407, A61K 3135, A61K 3140, C07D31160, C07D40712

Patent

active

058114483

ABSTRACT:
Substituted chromanylsulfonyl(thio)ureas, processes for their preparation, their use in pharmaceutical preparations, and pharmaceutical preparations comprising them
Chromanylsulfonyl(thio)ureas of the formula I ##STR1## are useful pharmaceuticals for the treatment of cardiac arrhythmias and for the prevention of sudden heart death due to arrhythmia. They can be used as antiarrhythmics and are suitable for the prevention of sudden heart death, for the treatment of cardiac insufficiency and also heart failure as a result of the effects of shock.

REFERENCES:
patent: 3780027 (1973-12-01), Cargoe et al.
patent: 3803176 (1974-04-01), Christensen et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5140039 (1992-08-01), DeBarbardus et al.
patent: 5185364 (1993-02-01), DeBarbardus et al.
patent: 5292755 (1994-03-01), Englert et al.
patent: 5294608 (1994-03-01), Lang et al.
patent: 5364868 (1994-11-01), Englert et al.
patent: 5373024 (1994-12-01), Lang et al.
patent: 5416094 (1995-05-01), Lal et al.
patent: 5516805 (1996-05-01), Lang et al.
patent: 5547953 (1996-08-01), Weichert et al.
patent: 5574069 (1996-11-01), Englert et al.
Duff, Henry J. et al., Circulation, 79(6), 1257-63 (1989).
Eur. Heart of J. 9(suppl. 1):25 and 167 (1988) book of abstracts.
Schmid, Andreas et al. Biochemical and Biophysical Research Comm. 112-117 (1992).
Scholz, Wolfgang et al. Cardiovascular Res. (1995) 29(2):260-8.
Rosskopf, Dieter et al. Cellular Physiology Biochem (1995), (5)4, 269-275.
Scholz, Wolfgang et al. Basic Research Cardiology 1993, 88(5), 443-55.
Sack, Stefan et al. J. Cardiovasc. Pharmacol. (1994)23(1), 72-78.
Kranzhofer, Roger et al. Circ. Res. (1993), 73(2), 264-8.
Scholz, Wolfgang et al. Br. J. Pharmacol. (1993), 109(2), 562-8.
Scholz, Wolfgang et al. J. Mol. Cell. Cardiol. (1992) 24(7), 731-39.
Scholz, Wolfgang et al. Cardiovascular Research. (Feb., 1995) vol. 29(2), 184-8.
Biological Chemistry Hoppe-Seyler (1991), vol. 372, No. 9, pp.750.
Faber, Sabine et al. Cell. Physiol. Biochem (1996), 6(1-2), 39-49.
Busch, Gillian L. et al. Pfluegers Arch. (1996), 431(5), 690-96.
Englert, Heinrich C. et al. Eur. J. Pharmacol. (1992), 210 (1), 69-75.
Mitsuka, Masayuki et al. Circulation Research (1993), vol. 73(2):269-275.

Affiliated with

Also associated with

Rating

Substituted chromanysulfonyl (thio) ureas, processing for their does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted chromanysulfonyl (thio) ureas, processing for their , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted chromanysulfonyl (thio) ureas, processing for their will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1622121