Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-07
1998-09-22
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 54, 514 61, 514 62, 536 172, 536 185, 536 53, 536 55, 536 551, 536 552, 536 553, 536124, A61K 3170, C07H 100, C07H 506
Patent
active
058114041
ABSTRACT:
The present invention relates to analogues of sialyl Le.sup.x the inhibit cellular adhesion between a selectin and cell that express sialyl Le.sup.x on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the celluar adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has a structure that corresponds to that of Formula A, ##STR1## wherein: Z is selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 acyl and ##STR2##
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De Frees Shawn
Gaeta Federico C. A.
Gaudino John J.
Hayashi Masaji
Zheng Zhongli
Cytel Corporation
Fonda Kathleen K.
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