Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as me

Details Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as me Oxime of 1, 2, 5, 6-tetrahydropyridine compounds their use as me

1988-08-22

1990-02-20

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546334, 546336, 546337, 546338, A61K 3144, C07D21170

Patent

active

049026992

ABSTRACT:
Compounds useful in the treatment of patients suffering from senile dementia, Alzheimer's disease or memory defects, of the formula ##STR1## in which R represents hydrogen or a linear, branched or cyclic alkyl, alkenyl, or alkynyl, containing up to 8 carbon atoms, or the radical ##STR2## in which R.sub.1 represents a linear or branched, alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, a linear or branched, saturated or unsaturated, alkoxy containing up to 8 carbon atoms, or aryl containing up to 14 carbon atoms, or the radical ##STR3## in which R.sub.2 represents a linear or branched alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, aryl containing up to 14 carbon atoms, possibly substituted, or aralkyl containing up to 18 carbon atoms, possibly substituted, and R' represents a linear, branched or cyclic alkyl, alkenyl or alkynyl, containing up to 8 carbon atoms, as well as their addition salts with organic or mineral acids.

REFERENCES:
patent: 3004979 (1961-10-01), Druey et al.
patent: 4710508 (1987-12-01), Bergmeier et al.
Jaffe Journal of the American Chemical Society, vol. 76, No. 13, Jul. 5, 1954, pp. 3527-3531.
Chemical Abstracts, vol. 92, No. 13, Mar. 31, 1980, p. 641, Abstract No. 110798y.

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