Plasminogen activator

Details Plasminogen activator Plasminogen activator

1986-10-03

1990-02-20

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435814, 435815, 4241951, C12N 924, A01N 6500, A61K 3578

Patent

active

049026232

ABSTRACT:
For selectively and reversibly adsorbing tPA, pro-tPA or mixtures thereof, from an aqueous medium, for example, derived from a melanoma cell culture, the aqueous medium is intimately contacted with an affinity reagent comprising an immobilized Kunitz-type inhibitor, substantially as occurs in and is extractable from seeds of an Erythrina species, e.g., Erythrina latissima, having Erythrina species, the following combination of characteristics:

REFERENCES:
patent: 4165258 (1979-08-01), Pye et al.
patent: 4245051 (1981-01-01), Reich et al.
Heussen et al., Haemostassis, 11 (Suppl. 1):47 (1982).
Rijken et al., J. Biol. Chem., 257(6):2920-2925 (Mar. 25, 1982).
Heussen et al., J. Biol. Chem., 259(19):11,635-11,638 (Oct. 10, 1984).

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