Human ostoclast-specific and -related genes

Details Human ostoclast-specific and -related genes Human ostoclast-specific and -related genes

1995-06-01

1997-08-12

Jones, W. Gary

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530324, 530325, 530326, 530327, 530356, 536 231, 536 232, C07K 500, C07K 1400, C07K 1451, C07H 2104

Patent

active

056567286

ABSTRACT:
The present invention relates to purified DNA sequences encoding all or a portion of an osteoclast-specific or -related gene products and a method for identifying such sequences. The invention also relates to antibodies directed against an osteoclast-specific or -related gene product. Also claimed are DNA constructs capable of replicating DNA encoding all or a portion of an osteoclast-specific or -related gene product, and DNA constructs capable of directing expression in a host cell of an osteoclast-specific or -related gene product.

REFERENCES:
patent: 5501969 (1996-03-01), Hastings et al.
Blair, Harry C., et al., "Extracellular-matrix degradation at acid ph Avian osteoclast acid collagenase isolation and characterization," Biochemical Journal 290 (3):873-884 (15 Mar. 1993).
Tezuka, Ken-Ichi, et al., "Identification of osteopontin in isolated rabbit osteoclasts," Biochemical and Biophysical Research Communications 186 (2):911-917 (31 Jul. 1992).
Tezuka, Ken-Ichi, et al., "Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts'," Journal of Biological Chemistry, 269(2) :1106-1109, (14 Jan. 1994).
Horton, M.A. et al., "Monoclonal Antibodies to Osteoclastomas (Giant Cell Bone Tumors): Definition ot Osteoclast-specific cellular Antigens," Cancer Research, 45:5663-5669 (Nov. 1985).
Davies, J. et al., "The Osteoclast Functional Antigen, Implicated in the Regulation of Bone Resoption, Is Biochemically Related to the Vitronectin Receptor," The J. of Cell Biology, 109:1817-1826 (Oct. 1989).
Hayman, A.R. et al., "Purification and Characterization of a Tartrate-resistant Acid Phosphatase from Human Ostoeclastomas," Biochem. J., 261:601-609 (1989).
Sandberg, M. et al., "Localization of the Expression of Types I, III, and IV Collagen, TGF-.beta.1 and c-fos Genes in Developing Human Calvarial Bones," Developmental Biology, 130:324-334 (1988).
Sandberg, M. et al., "Enhanced Expression of the TGF-.beta. and c-fos mRNAs in the growth Plates of Developing Human Long Bones," Development, 102:461-470 (1988).
Ek-Rylander, B. et al., "Cloning, Sequence, and Developmental Expression of a Type 5, Tartrate-Resistant, Acid Phosphatase of Rat Bone," The J. of Biological Chem., 266:24684-24689 (Dec. 25, 1991).
Schwabe, G., Database Genbank, Locus HSRPRNA (1 Page) Dec. 4, 1991.
Marzuki, S., Database Genbank, Locus MIHSGENOM (3 Pages) Aug. 27, 1992.

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