Aqueous peritoneal dialysis solution

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 23, 514561, 604 29, A61K 31195, A61K 3170, A61K 3802, A61M 128

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active

058278206

ABSTRACT:
The subject matter of this invention concerns an aqueous peritoneal dialysis solution which is obtained immediately prior to administration from two individual solutions, the first of which contains an osmotically active substance and the second of which contains bicarbonate ions, with the first individual solution containing anions of mono- and/or dicarboxylic acids and having a pH value of 4.5-5.8 and with the second individual solution containing an amino acid component or a peptide component and having a pH value of 7.2 to 10.0, and with the ready-to-use solution containing 23 to 26 mmoles/L bicarbonate ions and having a CO.sub.2 partial pressure of 25-70 mmHg and a pH value of 7.2 to 7.6

REFERENCES:
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patent: 4630727 (1986-12-01), Feriani et al.
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patent: 4997083 (1991-03-01), Loretti et al.
patent: 5011826 (1991-04-01), Steudle et al.
patent: 5158538 (1992-10-01), Shaw
patent: 5211643 (1993-05-01), Reinhardt et al.
patent: 5296242 (1994-03-01), Zander
Biasoli et al, "Sodium Lactate and Other Buffers for Peritoneal Dialysis," Contemporary Dialysis, pp. 46-49 (1982).
Feriani et al, "Bicarbonate Buffer for CAPD Solution," Trans Am Soc Artif Intern Organs, vol. XXXI, pp. 668-672 (1985).
Lindholm et al, "Amino acids for peritoneal dialysis: technical and metabolic implications," Peritoneal Dialysis, pp. 149-154 (1986).

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