Chemokine-like proteins and methods of use

Details Chemokine-like proteins and methods of use Chemokine-like proteins and methods of use

1994-10-26

1997-08-12

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

435 6952, 424 852, A61K 3820, C07K 1454

Patent

active

056567243

ABSTRACT:
The invention relates to novel chemokine-like proteins that include two or more newly discovered active domains from different chemokines. Active domains are regions of several contiguous amino acids that are necessary for chemokines' ability to suppress the proliferation of actively dividing myeloid cells, e.g., myeloid progenitor cells, myeloid stem cells, and leukemic cells. The new chemokine-like proteins provide higher myelosuppressive activity than naturally occurring, wild-type chemokines.

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