Veterinary pharmaceutical composition and method of administrati

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride

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424679, 424681, A61K 3306, A61K 3314

Patent

active

058275452

ABSTRACT:
A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene glycol, B vitamins and minerals. The calcium content of 25 grams per dose is lower than conventional calcium treatments used for this purpose. The propylene glycol gives the cow an energy boost and sweetens the taste so the cow does not object to it as it does to conventional gels and liquids. The B vitamins stimulate the cow's appetite. The minerals replace minerals lost in the milk and also help calcium absorption. The composition of the present invention is in a liquid form and is preferably administered using a 200 cc drench gun. The end of the dispensing tube of the drench gun is placed between the teeth and cheek of the cow and inserted all the way to the back of the cheek. A feature near the end of the dispensing tube causes a bulge in the cow's cheek which indicates the position of the dispensing tube from outside of the cow's mouth. The cow swallows the liquid mixture in a near normal manner which prevents the solution from being inhaled and causing aspiration pneumonia. The minimal irritation of the solution in the cow's throat allows the esophageal groove to open, thereby allowing the liquid into the omasum where absorption is faster than in the rumen where most of the other compositions for this purpose end up.

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Goff et al. "Calcium Salts for Treating Hypocalcemia: Carrier Effect Acid-Base Balance, and Oral Versus Rectal Administration", Journal of Dairy Science, vol. 77, No. 4 (Apr. 1994).

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