Polynucleotide compositions

Details Polynucleotide compositions Polynucleotide compositions

1994-11-18

1997-08-12

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424423, 424450, 424 7822, 424 7836, 536 245, 5147721, 526 72, A61K 4800, A61K 9127, C08F 200

Patent

active

056566115

ABSTRACT:
The invention provides compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. Preferably the polynucleotide complex will further include a polycationic polymer. In another aspect, the invention provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block. In yet another aspect, the invention provides polynucleotides that have been covalently modified at their 5' or 3' end to attach a polyether polymer segment. In still another aspect, the invention provides certain preferred polycationic polymers.

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