Pili of neisseria and vaccine compositions containing same

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

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424 85, 424 87, 424 88, 436511, A61K 3902, A61K 39095

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active

047692405

ABSTRACT:
It has been found that immunologically related piliated organisms exhibit a hierarchic relationship wherein the cross-reactivity of the antisera to first pili against second pill in the series is greater for the senior members of the series than the cross-reactivity of the first pili with the corresponding antisera from second pili. This asymmetric relationship leads to the situation where the juniormost pili in the series may be utilized to detect the presence of all members of the family senior to it and conversely the seniormost pili may be utilized to protect against infection by all strains junior in the series.

REFERENCES:
patent: 4203971 (1980-05-01), Buchanan
patent: 4461838 (1984-07-01), Brinton et al.
patent: 4601903 (1986-07-01), Frasch
patent: 4696896 (1987-09-01), Brinton et al.
Buchanan et al., J. Infect. Dis., 136, Supplement, Aug. 1977: S132-S137.
Tramont et al., J. Infections Diseases, v. 130, No. 3, 240-247, Sep. 1974.
Devoe et al., Infection and Immunity, vol. 10, 872-876, Oct. 1974.

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