Camphor compounds promote release of growth hormone

Details Camphor compounds promote release of growth hormone Camphor compounds promote release of growth hormone

1995-02-17

1997-08-12

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514255, 514278, 514319, 514325, 544383, 544391, 546 17, 546205, A61K 3116, A61K 31445, A61K 31495, A61K 3822

Patent

active

056566069

ABSTRACT:
The present invention is directed to certain novel compounds identified as camphor derivatives of the general structural formula: ##STR1## wherein A, X, Y, R.sup.2a, R.sup.4, and R.sup.5 are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

REFERENCES:
patent: 3239345 (1966-03-01), Hodge et al.
patent: 4036979 (1977-07-01), Asato
patent: 4411890 (1983-10-01), Momany
patent: 5204349 (1993-04-01), Bock et al.
patent: 5206235 (1993-04-01), Fisher et al.
R.G. Smith, et al., Science, Reprint Series, 11 Jun. 1993, vol. 260, pp. 1640-1643 "A Nonpeptidyl Growth Hormone Secretagogue".

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