Suppression of nitric oxide production by osteopontin

Details Suppression of nitric oxide production by osteopontin Suppression of nitric oxide production by osteopontin

1993-12-23

1997-12-09

Hutzell, Paula K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424 855, 4242781, 530351, 530330, 530326, 530300, 514 2, 514 12, A01N 3718, A61K 3800, A61K 3938, C07K 200

Patent

active

056957610

ABSTRACT:
The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders that involve inappropriate or detrimental NO activity. The invention particularly relates to modulation of kidney function. In specific embodiments, osteopontin and a 20-amino acid fragment of osteopontin that contains an Arg-Gly-Asp sequence suppress expression of inducible NO synthase mRNA, and osteopontin suppresses the activity of constitutive NO synthase.

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