Methods for treating post-exposure rabies and anti-rabies compos

Details Methods for treating post-exposure rabies and anti-rabies compos Methods for treating post-exposure rabies and anti-rabies compos

1994-06-08

1997-12-09

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241471, 42419611, 4241781, 4352351, 5303883, 5303873, A61K 39395, C07K 1608, C07K 1646

Patent

active

056957572

ABSTRACT:
Pharmaceutical compositions that comprise a pharmaceutically acceptable carrier or diluent and a antibodies that each comprise at least a portion of the variable region from MAb 1112-1 are disclosed. Methods of treating individuals suspected of exposure to rabies are disclosed.

REFERENCES:
Morrison, Hosp. Pract., 1989, 24:65-69, The Merck Manual of Diagnosis & Therapy, 16th Ed., 1992, pp. 205-208.
Harris and Emery, "Therapeutic Antibodies--the coming of age", TIB TECH 11: 42-44 (1993).
Osband and Ross, "Problems in the investigational study and clinical use of cancer immunotherapy", Immunology Today 11: 193-195 (1990).
Queen et al., "A Humanized Antibody that binds to the Interleukin 2 Receptor", Proc. Natl. Acad. Sci. USA 86: 10029-10033 (1989).
Reichmann et al., "Reshaping Human Antibodies for Therapy", Nature 332: 323-327 (1988).
Schumacher et al., "Use of Mouse Anti-Rabies Monoclonal Antibodies in Postexposure Treatment of Rabies", J. Clin Invest. 84: 971-975 (1989).
Winter and Milstein, "Man-made Antibodies", Nature 349: 293-299 (1991).
Wu and Kabat, "An Analysis of the Sequences of the Variable Regions of Bence Jones Proteins and Myeloma Light Chains and Their Implications for Antibody complementarity", J. Exp. Med 137: 211-250 (1970).

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