Prostaglandins

Details Prostaglandins Prostaglandins

1982-09-17

1984-03-20

Reamer, James H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424319, 424321, 424263, 560 12, 560 9, 560 21, 560 22, 560 35, 560120, 562429, 562430, 562426, 562435, 562437, 562440, 562502, 546332, 546333, 564 80, 564 85, 564 86, 564 87, C07C10327, A61K 3124

Patent

active

044381360

ABSTRACT:
Novel bicyclo [2,2,1] heptanes and hept-2-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by a grouping --C(R).dbd.N--NHCO--(NH).sub.a --R' in which R is hydrogen, an aliphatic hydrocarbon residue, an aromatic residue or an aliphatic hydrocarbon residue substituted by an aromatic residue, a is 0 or 1 and R' is an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

REFERENCES:
patent: 4073933 (1978-02-01), Shimomua et al.
Fitzpatrick et al., Nature, vol. 275, pp. 764-766 (1978).
Hensby et al., Adv. in Prostaglandin & Thromboxane Research, vol. 2, p. 864.
Leeney et al., Prostaglandins, vol. 11, pp. 953-960 (1976).
Katsube et al., Agricultural and Biochemical Chem., vol. 36, pp. 1997-2004 (1972).

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