Intraocular irrigating solution containing a polyamine antagonis

Details Intraocular irrigating solution containing a polyamine antagonis Intraocular irrigating solution containing a polyamine antagonis

1995-06-07

1997-02-18

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514912, A61K 31445

Patent

active

056042442

ABSTRACT:
Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more polyamine antagonists, and are useful for preventing or treating excitotoxicity associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.

REFERENCES:
patent: 4690931 (1987-09-01), Wick et al.
Beal, M. F., "Mechanisms of excitotoxicity in neurologic diseases," FASEB J., 6:3338-3344 (1992).
Choi, D. W., "Excitotoxic cell death," J. Neurobiol., 23:1261-1276 (1992).
Sattayasai, et al., "Morphology of quisqualate-induced neurotoxicity in the chicken retina," Invest. Ophthalmol. Vis. Sci., 28: 106-117 (1987).
Tung et al., "A quantitative analysis of the effects of excitatory neurotoxins on retinal ganglion cells in the chick," Visual Neurosci., 4:217-223 (1990).
Sisk et al., "Histological changes in the inner retina of albino rats following intravitreal injection of monosodium L-glutamate," Graefe's Arch. Clin. Exp. Ophthalmol., 223:250-258 (1985).
Siliprandi et al., "N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina," Visual Neurosci., 8:567-573 (1992).
Reif-Lehrer et al., "Effects of monosodium glutamate on chick embryo retina in culture," Invest. Ophthalmol. Vis. Sci., 14(2):114-124 (1975).
Blanks, J. C., "Effects of monosodium glutamate on the isolated retina of the chick embryo as a function of age: A morphological study," Exp. Eye Res., 32:105-124 (1981).
Olney et al., "The role of specific ions in glutamate neurotoxicity," Neurosci. Lett., 65:65-71 (1986).
Olney et al., "The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnotics," Neurosci. Lett 68:29-34 (1986).
Price et al., "CNQX potently and selectively blocks kainate excitotoxicity in the chick embryo retina," Soc. Neurosci. Abst., 14:418 (1988).
David et al., "Involvement of excitatory neurotransmitters in the damage produced in chick embryo retinas by anoxia and extracellular high potassium," Exp. Eye Res., 46:657-662 (1988).
Caprioli et al., "Large retinal ganglion cells are more susceptible to excitotoxic and hypoxic injury than small cells," Invest. Ophthalmol. Vis. Sci., 34(Suppl):1429 (1993).
Cummins et al., "Electrophysiology of cultured retinal ganglion cells to investigate basic mechanics of damage," Glaucoma Update IV, 59-65 (1991).
Sucher et al., "N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro," J. Neurosci., 11(4):966-971 (1991).
Massey, S., "Cell types using glutamate as a neurotransmitter in the vertebrate retina," N. N. Osborne and G. J. Chader (Eds.) Progress in Retinal Research, Ch. 9, Pergammon Press: Oxford, 399-425 (1990).
Miller et al., "Excitatory amino acid receptors in the vertebrate retina," in Retinal Transmitters and Modulators: Models for the Brain, (W. W. Morgan, Ed.) CRC Press, Inc., Boca Raton, II:123-160 (1985).
Zeevalk et al., "Action of the anti-ischemic agent infenprodil on N-methyl-D-aspartate and kainate-mediated excitotoxicity," Brain Res., 522:135-139 (1990).
Ornstein et al., "Antagonists of the NMDA receptor complex," DN&P, 7(1):5-12 (1994).
Lipton, S. A., "Prospects of clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide," TINS, 16(12): 527-532 (1993).

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