Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-06
1997-02-18
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546103, C07D21906, C07D40112, A61K 31435, A61K 3147
Patent
active
056042370
ABSTRACT:
These are provided compounds of formula I ##STR1## wherein A represents an oxygen or a sulphur atom, a bond or a group (CH.sub.2).sub.1 NR.sup.9 (where 1 represents zero or 1 and R.sup.9 represents a hydrogen atom or a methyl group); B represents a C.sub.1-4 alkylene chain optionally substituted by a hydroxyl group, except that the hydroxyl group and moiety A can not be attached to the same carbon atom when A represents an oxygen or sulphur atom or a group (CH.sub.2).sub.1 NR.sup.9, or when A represents a bond B may also represent a C.sub.2-4 alkenylene chain; R.sup.3 represents a hydrogen atom or a C.sub.1-4 alkyl group; m represents 1 or 2; R.sup.7 represents a hydrogen atom or R.sup.3 and R.sup.7 together form a group --(CH.sub.2).sub.n -- where n represents 1 or 2. These compounds can sensitize multidrug-resistant cancer cells to chemotherapeutic agents and may be formulated for use in therapy, particularly to improve or increase the efficacy of an antitumor drug.
REFERENCES:
patent: 4021551 (1977-05-01), Cullen
patent: 4127573 (1978-11-01), Gorvin
patent: 4250182 (1981-02-01), Gorvin
patent: 4479000 (1984-10-01), Rewcastle et al.
patent: 4590277 (1986-05-01), Atwell et al.
patent: 4803204 (1989-02-01), Dhar
patent: 5240936 (1993-08-01), Chiou
patent: 5296602 (1994-03-01), Su et al.
Hyafil et al., Cancer Research, 53, 4595-4602, Oct. 1, 1993.
Rewcastle et al., Synthetic Communications, 17(3), 309-317, 1987.
Palmer et al. J. Med. Chem vol. 31 pp. 707-712 (1988).
Denny et al, J. Med. Chem vol. 30 pp. 658-663 (1987).
Hyafil, et al. CA Previews vol. 93, abstract 502037 (1993).
Dodic Nerina
Dumaitre Bernard A.
Daus Donald G.
Laboratoires Glaxo SA
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