Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyr

Details Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyr Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyr

1982-03-16

1984-10-09

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546 94, 546 95, 546 62, 568633, 568634, 549276, 549278, C07D45506, C07D48714, A61K 3147

Patent

active

044761317

ABSTRACT:
Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R.sub.1 is H or certain acyl groups; Q is CO.sub.2 R.sub.4, COR.sub.5, C(OR.sub.7)R.sub.5 R.sub.6, CN, CONR.sub.9 R.sub.10, CH.sub.2 NR.sub.9 R.sub.10, CH.sub.2 NHCOR.sub.11, CH.sub.2 NHSO.sub.2 R.sub.12, 5-tetrazolyl or when n is 1, Q and OR.sub.1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.

REFERENCES:
patent: 4188495 (1980-02-01), Althuis et al.
patent: 4260764 (1981-04-01), Johnson

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