MR studies in which a paramagnetic gas is administered to a livi

Details MR studies in which a paramagnetic gas is administered to a livi MR studies in which a paramagnetic gas is administered to a livi

1996-04-17

1997-12-09

Lateef, Marvin M.

Surgery

Truss

Pad

1286532, 128654, 128716, 424 93, A61B 5055

Patent

active

056949340

ABSTRACT:
A paramagnetic gas such as oxygen is administered twice at different concentrations to a living patient, as by causing the patient to breathe air and causing the patient to breathe pure oxygen. Two T1-weighted MR images are then acquired of a region in which the gas is present; advantageously, the region includes the patient's lungs. Because the paramagnetic gas shortens the T1 relaxation time of e.g. the patient's lung tissue, a comparison of the T1-weighted MR images shows where the gas has reached the patient's lung tissue and where the gas has been prevented from reaching the patient's lung tissue. This permits the radiologist to carry out e.g. a ventilation study without administering a radioactive material to the patient.

REFERENCES:
Magnetic Resonance in Medicine, vol. 33, pp. 271-275 (1995), `MR Imaging with Hyperpolarized .sup.3 He Gas`, Hunter Middleton et al.
Radiology 1992, vol. 183, pp. 667-672, `Contrast-enhanced MR Imaging of the Lung: Assessments of Ventilation and Perfusion.sup.1 `, Berthezene, MD et al.
Nature, vol. 370, pp. 199-200 (1994), `Biological magnetic resonance imaging using laser-polarized .sup.129 Xe`, M.S. Albert et al.
CT, vol. 5, No. 6, pp. 543-546 (1981), `Enhancement of Relaxation Rate with Paramagnetic Contrast Agents in NMR Imaging`, I.R. Young, Ph.D. et al.

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