Substituted pyrimid-2-ones, the salts thereof, processes for the

Details Substituted pyrimid-2-ones, the salts thereof, processes for the Substituted pyrimid-2-ones, the salts thereof, processes for the

1982-09-10

1984-10-23

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544316, C07D23936, A61K 31505

Patent

active

044788398

ABSTRACT:
Compounds of general formula: ##STR1## (wherein X represents a halogen atom or a trifluoromethyl group; R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, or a C.sub.1-4 alkyl group, and R.sup.3 represents a hydrogen atom or a C.sub.1-5 saturated or unsaturated, straight or branched acyclic aliphatic group; a C.sub.3-8 saturated or unsaturated cyclic aliphatic group; a heterocyclic substituted aliphatic group; an araliphatic group; or a heterocyclic or carbocyclic aryl group; any of said groups optionally carrying one or more substituents selected from halogen, oxo, hydroxy, mercapto, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkanoyloxy and amino) and, where an acidic or basic group is present, physiologically compatible salts thereof have been found to be of use in combating abnormal cell proliferation.
The compounds of formula I may be prepared by reaction of a 5-halo- or 5-trifluoromethyl-pyrimidin-2-one with an appropriate isocyanate.

REFERENCES:
patent: 4052400 (1977-10-01), Schwam
patent: 4395406 (1983-07-01), Gacek
March, Advanced Organic Chemistry, p. 823 (1977).
Japanese Abstracts, vol. 1, No. 120, dated Oct. 12, 1977, p. 2695 C 77.

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