Derivatives of pyroglutaminic acid preparation process and appli

Details Derivatives of pyroglutaminic acid preparation process and appli Derivatives of pyroglutaminic acid preparation process and appli

1997-08-18

2000-05-02

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514343, C07D40106, A64K 3144

Patent

active

06057450&

ABSTRACT:
The new derivatives of pyroglutaminic acid have the formula (I) wherein R.sup.1, R.sup.2 and R.sup.3 are H or COR.sup.4, R.sup.4 being lower alkyl or aryl, A.sup.- is Cl.sup.-, CH.sub.3 COO.sup.- and OH.sup.- and the ondulated line means that the substituent occupies any of the possible spatial positions. The process comprises the reaction of serine with pyridine and acetic anhydrid. These compounds may be applied in immunology as modifiers of the biological immune response, in the "integral" treatment of cancer and prevention or treatment of serious systemic infections in "high risk" patients suffering of chronical diseases and secondary immunodeficiency (cancer, AIDS, Diabetes Mellitus), or primary immunodeficiency (syndromes of DiGeorge, Down). ##STR1##

REFERENCES:
Anderson et al. (1992) J. Immunol. 11:119/.
Bernengo et al. (1984) In: Immunomodulation, Fudenberg et al., rd., Plenum Press, New York, pp.43, 58-65.
Bespalova, G.V. et al. (1981) L.K. Pharm. Chem. J. 15:643-5.
Bespalova, G.V. et l. (1991) Pharm. Chem. J. 25:40-43.
Cohen et al. (1979) JAMA 241:1813-5.
Dillman et al. (1992) J. Immunol. 11:124.
Ganser et al. (1989) Ann. Internal Med. 111:887-92.
Gipponi et al. (1985) Italian J. Surgical Sci. 15:243-8.
Goldstein et al. (1985) 3rd Int. Conf. Immunopharmacol., Florence, 5/6-11, Abst.
Gundermann, K.D. et al. (1964) Chem. Bor. 97:647-52.
Herrmann et al. (1989) J. Clin. Oncol. 7:159-67.
Kalinowski et al. (1988) In: .sup.13 C--NMR--Spektroskopie, John Wiley & Sons, Chichester, New York, pp. 382-3.
Kleinerman et al. (1989) Cancer Res. 49:4665-70.
Komeno et al. (1952) Chem. Abst. 46:Abst..TM.8118c (J. Pharm. Soc. Japan. 71:646-8).
Mitchell, M.S. (1993) In: Biological Approaches to Cancer Treatment-Biomodulation, Mitchell, M.S. ed., McGraw-Hill, Inc., New York, pp.352, 366, 378,394,398,476,498,500,514.
Oldman et al. (1983) J. Biol. Response Modif. 2:1-37.
Oettgen et al. (1991) Curr. Opin. Immunol. 3:699-705.
Rahman et al. (1991) J. Immunol. 10:221-5.
Rosenberg, S.A. (1988) In: Important Advances in Oncology, DeVita, Jr. et al. ed., J.B. Lippincott Company, Pennsylvania, pp.217,229,240,252.
Solans et al. (1990) In: Free Papers Printed in Full, U. of Milan, Montorsi et al., ed., Monduzzi Editore S.p.A., Bologna, Italy, pp.I63-67.
Swain, S.L. (1993) J. Immunol. 14:150-4.
Trainin et al. In: Thymic Factor Therapy, Byrom et al. ed., Raven Press, New York, pp.189-97.
Waldman, T.A. (1991) Science 252:1657-62.
Woodruff, M.A. (1980) In: The Interaancer and Host: Its Therapeutic Significance, Grune & Stratton, New York, pp.237-8,249-50,271.
Bespalova, G.V. et al,; Synthesis and Antimic gobial activity of Morphaline derivatives of 2-pyrrolidone and theis Thio Analogs Phasm. Chem. Journal vol. 25, pp. 40-43, 1991.

Affiliated with

Also associated with

Rating

Derivatives of pyroglutaminic acid preparation process and appli does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of pyroglutaminic acid preparation process and appli, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of pyroglutaminic acid preparation process and appli will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1594964