Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-06-11
2000-05-02
Trinh, Ba K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549510, 549511, 424450, 424489, 424502, A61K 31335, C07D30514
Patent
active
060573597
ABSTRACT:
Spontaneously dispersible concentrates comprising new esters of Baccatin-III, 10-Deacetylbaccatin-III and 14-OH-10-Deacetylbaccatin-III, procedures for their production. The preparation of aqueous ultramicroemulsions, their incorporation into pharmaceutical compositions having antitumor, antiviral and virucidal activity, are efficacious in the treatment of eczemae and psoriasis and stimulate the increased absorption of exogenous activators, regulators or modulators, are described.
REFERENCES:
patent: 5478860 (1995-12-01), Wheeler et al.
patent: 5580889 (1996-12-01), Mayhew et al.
patent: 5739016 (1998-04-01), Hanson et al.
Eugster et al., "Marigenol-Concentrates Comprising Taxol and/or Taxan esters as active Substances" Panminerva Medica 38:234-242 (1996).
Benita et al. "Submicron Emulsions as Colloidal Drug Carriers for Intravenous Administraction:Comprehensive Physicochemical Characterization" Journal of Pharmaceutical Sciences 82:1069-1079 (1993).
Pauwels et al. "Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus" Journal of Virological Methods 16:171-185 (1987).
Bergamini et al. "A tetrazolium-based colorimetric assay for quantification of HIV-1-induced cytopathogenicity in monocyte-macrophages exposed to macrophagecolony-stimulating factor" Journal of Virological Methods, 40, pp. 275-286, 1992.
Levy, HIV research: a need to focus on the right target The Lancet 345:1619-1621 (1995).
Chan et al., "Taxa-4(16)-diene-5.alpha.,9.alpha., 10.beta., 13.alpha.-tetraol, a New Taxane Derivative from the Heartwood of Yew (T. baccata L):X-Ray Analysis of a p-Bromobenzoate Derivative" Chemical Communications pp. 923-925, No. 24, 1966.
Della Casa De Marcano et al. "The Structure of Baccatin-III, a Partially Esterified Octahydroxy-monoketo-taxane Derivative Lacking a Doble Bond at C-4" Chemical Communications pp. 216-217, 1970.
Della Casa De Marcano et al. "Structure of Some Taxane Diterpenoids, Baccatins-III, IV,--VI, and VII and 1-Dehydroxybaccatin-IV, Possessing an Oxetan Ring" J.C.S. Chem. Comm. pp. 365-366 (1975).
Fleming et al., "Biosynthesis of Taxoids, Mode of Attachment of the Taxol Side Chain" J. Am. Chem. Soc. 116:4137-4138 (1994).
Gisler et al. "Mode-selective dynamic light scattering: theory versus experimental realization" Applied Optics 34:3546-3553 (1995).
Appendino et al., 14.beta.-Hydroxy-10-deacetylbaccatin III, a New taxane from Himalayan Yew (Taxus wallichiana Zucc.) J. Chem. Soc. Perkin Trans. 1 pp. 2925-2929 (1992).
Appendino et al., "New Oxetane-type Taxanes from Taxus wallichiana Zucc." J. Chem Soc. Perkin Trans 1 pp. 1563-1566 (1993).
Marigen S.A.
Trinh Ba K.
LandOfFree
Spontaneously dispersible concentrates comprising esters of bacc does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Spontaneously dispersible concentrates comprising esters of bacc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Spontaneously dispersible concentrates comprising esters of bacc will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1594304