Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-12-12
2000-05-02
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514383, 514398, 514407, 514396, 514399, 514255, 514256, 514258, 514261, A61K 3141, A01N 4364
Patent
active
060573465
ABSTRACT:
A class of calcium-response modification compounds is disclosed which inhibits the activation of retroviral LTR promoters, including the HIV-LTR. This class of compounds are used to delay or suppress the transition of a retroviral infection from a latent to a virulent condition, thereby ameliorating retrovirally caused diseases such as AIDS. The compounds are also useful in cancer treatment, allowing for coordinated therapeutic approaches to retroviral diseases and related cancers such as AIDS and Kaposi's Sarcoma. The compounds are also useful in standardizing in vitro assays of clinical and experimental importance.
REFERENCES:
patent: 4000197 (1976-12-01), Barfknecht et al.
patent: 4289787 (1981-09-01), Molloy et al.
patent: 5132315 (1992-07-01), Kohn et al.
patent: 5359078 (1994-10-01), Kohn et al.
Horluism et al, 1991, Jap Infects Diseases vol. 164 pp. 53-60.
Aaronson, Science 254:1146-1153 (1991).
Berridge, et al., Nature 341:197-205 (1989).
Chapron, et al., Biochem. Biophs. Res. Comm. 158:527-533 (1989).
Chuvpilo et al. (1993) Nuc. Acids Res. 21(24): 5694-5704.
Clark, et al., Cell. 65:1043-1051 (1991).
Cole et al., Cancer Metastasis Rev. 13(1): 31-44 (1994).
Felder, et al., J. Pharm. Exp. Therapeut. 257:967-971 (1991).
Gusovsky, et al., J. Biol. Chem. 268:7768-7772 (1993).
Hupe, et al., J. Biol. Chem. 266:10136-10142 (1991).
Kohn, et al., J. Natl. Cancer Inst. 82:54-60 (1990).
Kohn, et al., Cancer Res. 52:3208-3212 (1992).
Lowenthal (1988) Proc. Natl. Acad. Sci. USA 85: 4468-4472.
Masuda et al. (1993) Molecular and Cellular Biology 13(12): 7399-7407.
Merritt, et al., J. Biol. Chem 271:515-522 (1990).
Shaw, et al. (1988), Science 241: 202-205.
Siekevitz et al., Science (1987) 238 (4833): 1575-1578.
Tanaguchi, et al., J. Biol. Chem. 268:2277-2279 (1993).
Arjona et al., "Sterochemistry of the reduction of the imino group. IV. Sterochemistry of the reduction of N-(1-phenylethyl)-1-alkyl-1-arylmethanimines," An. Quim. Ser. C 81(1):23-29 (1985).
Freifelder, "Selective Hydrogenolysis. Dehalogenation in the Presence of N-Benzyl Linkage," J. Org. Chem. 31(11):3875-3877 (1966).
Grethe et al., "Syntheses in the Isoquinoline Series. Synthesis of 2,3-Dihydro-4(1H)-isoquinolones," J. Org. Chem. 33(2):491-494 (1968).
Hiroi et al., "A Highly Efficient and Recyclable Chiral Director for Asymmetric Synthesis of Sulfoxides," Chemistry Letters pp. 1595-1598 (1980).
Hiroi et al., "Studies on Chiral Organo-Sulfur Compounds. I. Asymmetric Synthesis of Sulfoxides with Optically Active o-Aminoalkylphenol Derivatives," Chem. Pharm. Bull. 31:3471-3485 (1983).
Kametani et al., "Studies on the Synthesis of Heterocyclic Compounds. Part 687. Asymmetric Synthesis of Salsolidine," J. Chem. Soc. Perkin Trans. 1 pp. 579-581 (1977).
Kang et al., "Rhodium(I)-catalysed Asymmetric Hydrogenation of Imines," J. Chem. Soc. Chem. Commun. pp. 1466-1467 (1988).
Kienzle et al., "1,5-Dihydroimidazoquinazolinones as blood platelet aggregation inhibitors," Eur. J. Med. Chem.--Chem. Ther. 17:547-556 (1982).
Kozlov et al., "Reductive animation of 1-acetylcyclohexene by nitriles," Vestsi Akad. Navuk BSSR, Ser. Khim. Navuk pp. 55-58 (1977.
Mori et al., "Formic Acid Reduction. XI. Reduction of Schiff Bases," Chem. Pharm. Bull. 19:1722-1727 (1971).
Standridge et al., "Phenylalkylamines with Potential Psychotherapeutic Utility. 1. 2-Amino-1-(2,5-dimethoxy-4-methylphenyl) butane," J. Med. Chem. 19:1400-1404 (1976).
Standridge et al., "Phenylalkylamines with Potential Psychotherapeutic Utility. 2. Nuclear Substituted 2-Amino-1-phenylbutanes," J. Med. Chem. 22:154-162 (1980).
Hashimoto et al., "Highly Diastereoselective Addition of Organometallic Reagents to Chiral Almines Derived from 1-(2-Methoxyphenyl) ethylamine," Synlett 9:961-962 (1995).
Majewski and MacKinnon, "Enantioselective deprotonation of protected 4-hydroxycyclohexanones," Can. J. Chem. 72(7):1699-1704 (1994).
Wang and Backvall, "Ruthenium-catalysed Transfer Hydrogenation of Imines by Propan-2-ol," J. Chem. Soc., Chem. Commun. pp. 980-982 (1992).
Gardner Kevin L.
Kohn Elise C.
Liotta Lance A.
Reamer James H.
The United States of America as represented by the Department of
LandOfFree
Inhibition of retroviral LTR promoters by calcium response modif does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of retroviral LTR promoters by calcium response modif, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of retroviral LTR promoters by calcium response modif will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1594181