Methods for treating cancers and restenosis with p21

Details Methods for treating cancers and restenosis with p21 Methods for treating cancers and restenosis with p21

1998-02-26

2000-05-02

Hauda, Karen M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435375, 435440, 435455, 435475, 435476, A61K 4800, C12N 510, C12N 1509, C12N 1563

Patent

active

060573007

ABSTRACT:
The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G.sub.0 /G.sub.1, alteration in morphology, and cell differentiation.

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