Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-09-27
2000-05-02
Campell, Bruce R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 231, 536 241, 435 691, 4353201, 435325, 435455, 435458, 424 9321, A61K 4800
Patent
active
06057299&
ABSTRACT:
The invention provides a human prostate-specific transcriptional regulatory sequence, polynucleotide comprising such regulatory regions, toxin gene constructs wherein a toxin gene is expressed under the transcriptional control of a human prostate-specific transcriptional regulatory sequence, and methods for treating prostate disease using such toxin gene constructs.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 5698443 (1997-12-01), Henderson et al.
Allison, J. et al. "Tissue-specific and hormonal regulation of the genes for rat prostatic steroid-binding protein in transgenic mice" Molecular and Cellular Biology(1989)9(5):2254-2257.
Banas et al. "Analysis of the promoter of the human prostatic acid phosphatase gene" Biochimica et Biophysica Acta(1994)1217:188-194.
Slawin et al. "Transgenic Studies: Evidence that a prostate-specific promoter acts by silencing inapporiate expression sites" Journal of Urology(1992)147(4 Suppl.):319A.
Taneja et al. "Construction of a prostate specific antigen promoter-driven gene transfer vector:a novel strategy for target specific gene therapy in prostate cancer" Journal of Urology(May 1994)151(5 Suppl.):491A.
Adair et al., "Targeted homologous recombination at the endogenous adenine phosphoribosyltransferase locus in Chinese hamster cells" Proc. Natl. Acad. Sci. (USA) (1989)86:4574-4578.
Allan et al., "Synergism between Steroid Response and Promoter Elements during Cell-free Transcription" J. Biol. Chem. (1991)226:5905-5910.
An et al., "Expression of bacterial .beta.-galactosidase in animal cells" Mol. Cell. Biol. (1982) 2:1628-1632.
Bagchi et al., "Steroid Hormone-Dependent Interaction of Human Progesterone Receptor with its Target Enhancer Element" Mol. Endocrinol. (1988)2:1221-1229.
Beato, "Gene Regulation by Steroid Hormones" Cell (1989)56:335-344.
Behr et al., "Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA" Proc. Natl. Acad. Sci. (USA) (1989)86:6982-6986.
Behringer et al., "Dwarf mice produced by genetic ablation of growth hormone-expressing cells" Genes & Dev. (1988) 2:453-461.
Bradshaw et al., "A Steroid Response Element can Function in the Absence of a Distal Promoter" Mol. Endocrinol. (1988) 2:1286-1993.
Brewster et al., "Gene therapy in urological oncology: principles, strategies and potential" Eur. Urol. (1994)25:177-182.
Brinster et al., "Introns increase transcriptional efficiency in transgenic mice" Proc. Natl. Acad. Sci. (USA) (1988) 85:836-840.
Capecchi, "Altering the Genome by Homologous Recombination" Science (1989) 244: 1288-1292.
Chaudhary et al., "Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity" Proc. Natl. Acad. Sci. (USA) (1990)87:308-312.
Cornetta et al., "No Retroviremia or Pathology in Long-Term Follow-Up of Monkeys Exposed to a Murine Amphotropic Retrovirus" Hum. Gene Ther. (1991) 2:215-219.
Dean et al., "Effects of Exogenous Amines on Mammalian Cells, will Particular Reference to Membrane Flow" Biochem. J. (1984) 217:27-40.
Dignam et al., "Accurate Transcription Initiation by RNA Polymerase II in a Soluble Extract From Isolated Mammalian Nuclei" Nucl. Acids Res. (1983) 11:1475-1489.
Eckert et al., "DNA Polymerase Fidelity and the Polymerase Chain Reaction" PCR Methods and Applications (1991) 1:17-24.
Felgner et al. "Lipofection: A Highly Efficient, Lipid-Mediated DNA-Transfection Procedure" Natl. Acad. Sci. USA (1987) 84:7413-7417.
Frankel et al., "Selection and Characterization of Ricin Toxin A-Chain Mutations in Saccharomyces cerevisiae" Mol. Cell. Biol. (1989) 9:415-420.
Gao et al., "A Novel Cationic Liposome Reagent For Efficient Transfection of Mammalian Cells" Biochem. Biophys. Res. Commun. (1991) 179:280-285.
Ghadzizadeh et al., "Prostatic Origin of Metastases: Immunoperoxidase Localization of Prostate-Specific Antigen" Urol. Int. (1984) 39:9-12.
Gotoh et al., "New strategy of toxic gene therrapy for human prostate cancer cells" J. Urol. (1995) 153:308A (abstract No. 320).
Haddada et al., "Adenoviral Interleukin-2 Gene Transfer into P815 Tumor Cells Abrogates Tumorigenicity and Induces Antitumoral Immunity in Mice" Human Gene Therapy (1993) 4: 703-711.
Hamdy et al., "Circulating Prostate Specific Antigen-positive Cells Correlate with Metastatic Prostate Cancer" Br. J. Urol. (1992) 69:392-396.
Henttu et al., "cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes" Biochemical and Biophysical Research Communications (1989) 160:903-910.
Ho et al., "Interactions Of Antigen-Sensitized Liposomes With Immobilized Antibody: A Homogenous Solid-Phase Immunoliposome Assay" J. Immunol. (1985) 134:4035-4040.
Hogan et al., Manipulating the Mouse Embryo: A Laboratory Manual, (1988) Cold Spring Harbor Laboratory. The title page and table of contents are included herewith.
Horoszewicz et al., "LNCaP Model of Human Prostatic Carcinoma" Cancer Res. (1983) 43:1809-1818.
Hwang et al., "Functional Domains of Pseudomonas Exotoxin Identified by Deletion Analysis of the gene Expressed in E. Coli" Cell (1987) 48:129-136.
Innis et al., eds., PCR Protocols: A Guide to Methods and Applications, (1990) Academic Press. The title page and table of contents are included herewith.
Johnson et al., "Targeting of Nonexpressed Genes in Embryonic Stem Cells via Homologous Recombination" Science (1989) 245:1234-1236.
Kolberg, "Gene-Transfer Virus Contaminant Linked To Monkey's Cancer" J. NIH Res. (1992) 4:43-44.
Kovarik et al., "Analysis of the Tissue-specific Promoter of the MUCI Gene" J. Biol. Chem. (1993) 268:9917-9926.
Lamb et al., "Nucleotide Sequence of Cloned cDNA Coding for Preproricin" Eur. J. Biochem (1985) 148:265-270.
Lemaigre et al., "Liver-specific Factor Binding to the Liver Promoter of a 6-Phosphofructo-2-kinase/Fructose-2, 6-bisphosphatase Gene" J. Biol. Chem. (1993) 268:19896-19905.
Litzinger et al., "Phosphatidylethanolamine liposomes: Drug Delivery, Gene Transfer and Immunodiagnostic Appications" Biochem. Biophys. Acta (1992) 1113:201-227.
Luke et al., "Human Androgen Receptor Binding to the Androgen Response Element of Prostate Specific Antigen" J. Androl. (1994) 15:41-51.
Lundwall, "Characterization of the Gene for Prostate-Specific Antigen, a Human Glandular Kallikrein" Biochem. and Biophys. Res. Commun. (1989) 161:1151-1159.
Lundwall et al., "Molecular Cloning of Human Prostate Specific Antigen cDNA" FEBS Lett. (1987) 214:317-322.
Mannino et al., "Liposome Mediated Gene Transfer" Biotechniques (1988) 6:682-690.
Mansour et al., "Disruption of the Proto-oncogene int-2 in Mouse Embryo-Derived Stem Cells: a General Strategy for Targeting Mutations to Non-Selectable Genes" Nature (1988) 336:348-352.
Mattila et al., "Fidelity of DNA Synthesis by the Thermococcus litoralis DNA Polymerase--an Extremely Heat Stable Enzyme with Proofreading Activity" Nucleic Acids Res. (1991) 19:4967-4973.
Maxwell et al., "Cloning, Sequence Determination, and Expression in Transfected Cells of the Coding Sequence for the tox 176 Attenuated Diphtheria Toxin A Chain" Mol. Cell. Biol. (1987) 7:1576-1579.
Maxwell et al., "Regulated Expression of Diphtheric Toxin A-Chain Gene Transfected into Human Cells: Possible Strategy for Inducing Cancer Cell Suicide" Cancer Res. (1986) 46:4660-4664.
Messing et al., "P.sub.o Promoter Directs Expression of Reporter and Toxin Genes to Schwann Cells of Transgenic Mice" Neuron (1992) 8:507-520.
Meyer et al., "Steroid hormone receptors compete for factors that mediate their enhancer function" Cell (1989) 57:433-442.
Miller et al., "Gene Transfer by Retrovirus Vectors Occurs Only in Cells that are Actively Replicating at the Time of Infection" Mol. Cell. Biol. (1990) 10: 4239-4242.
Mitchell et al., "Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins" Science (1989) 245:371-378.
Mocellini et al., "Finasteride (MK-906) in the Treatment of Benign Prostatic Hyperphlasia" The Prostate (1993) 22:291-299.
Moss, Vaccinia virus: A tool for research and vaccine development (1991) 252:1662-1667.
Nabel et al., "Immunother
Calydon, Inc.
Campell Bruce R.
Nguyen Dave Trong
LandOfFree
Tissue-specific enhancer active in prostate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tissue-specific enhancer active in prostate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue-specific enhancer active in prostate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1593889