Recombinant viral vector system

Details Recombinant viral vector system Recombinant viral vector system

1995-06-06

2000-05-02

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 2372, 536 241, C12N 1586, C07H 2104

Patent

active

060571527

ABSTRACT:
The present invention relates to a system for replication and encapsidation of recombinant DNA fragments into virus particles comprised of adenovirus associated viral (AAV) capsid proteins. The invention provides an means of obtaining recombinant viral stocks that may be used to treat patients suffering from genetic diseases.

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patent: 5478745 (1995-12-01), Samulski et al.
Samulski et al., J. Virol., vol. 63, No. 9, pp. 3822-3828, Sep. 1989.
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Samulski, R.J. et al., 1982, "Cloning of Adeno-Associated Virus into pBR322: Rescue of Intact Virus From the Recombinant Plasmid in Human Cells", Proc. Natl. Acad Sci. USA 79:2077-2081.
Miller, A.D., 1990, "Retrovirus Packaging Cells", Human Gene Therapy 1:5-14.
Kotin, R. et al., 1990, "Site-Specific Integration by Adeno-Associated Virus", Proc. Natl. Acad. Sci. USA 87:2211-2215.
Samulski, R. et al., 1991, "Targeted Integration of Adeno-Associated Virus (AAV) into Human Chromosome 19", EMBO J. 10:3941-3950.
Muzyczka, N., 1992, "Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells", Current Topics in Microbiol. & Immunol., 158:97-129.
Philip, R. et al., 1994, "Efficient and Sustained Gene Expression in Primary T Lymphocytes and Primary and Cultured Tumor Cells Mediated by Adeno-Associated Virus Plasmid DNA Complexed to Cationic Liposomes", Mol. Cell. Biol. 14:2411-2418.

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