Compositions, processes for their preparation and method for tre

Details Compositions, processes for their preparation and method for tre Compositions, processes for their preparation and method for tre

1980-03-05

1983-11-15

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424177, 424180, 435 68, 435 69, 435172, 435240, 2601125R, 260112R, A61K 3710, A61K 3512, A61K 3900, C12P 2100, C12P 2106, C12N 1500, C12N 500

Patent

active

044155530

ABSTRACT:
The invention comprises preparations for the treatment of neoplasms, the methods of treatment of neoplasms using such preparations, and processes for preparing such preparations, including the step of selective enzymatic degradation of the nuclei of cancer cells.
The invention further comprises the method of treating patients suffering from neoplasms with immunomodulating agents obtained by isolating the genetically active components of cancer cell nuclei obtained from cancer tissue, subsequently recombining them by specific hybridization steps to prepare a vaccine therefrom, and intravenously, intraperitoneally and/or intramuscularly administering the resulting vaccine product to patients. The neoplastic tissue used may be obtained by surgical removal either from the diseased portion of the patient's body who suffers from the neoplasm or from another patient who suffers from the same or similar type and form of neoplasm as the patient to be treted by said method, or from tumors transplanted into animals or from virus-, chemically-, irradiation-caused tumors in animals or from spontaneous tumors in animals.

REFERENCES:
Matsubara, Chem. Abs., vol. 56, 1962, p. 2838g.
Irie, Int. J. Cancer, vol. 6, 1970, p. 304.
Irie, Int. J. Cancer, vol. 4, 1969, p. 150.
Irie, Cancer Res., vol. 31, 1971, p. 1682.

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