Composition for establishing immunological tolerance

Details Composition for establishing immunological tolerance Composition for establishing immunological tolerance

1979-12-05

1983-11-15

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424177, 424180, 424271, 424278, 436530, 260112R, 536 32, 536 43, 536 98, A61K 3935, A61K 39385, A61K 3939, A61K 3172, A61K 3173, A61K 4700

Patent

active

044155522

ABSTRACT:
A water-soluble non-immunogenic carrier, namely carboxymethyl cellulose, is provided which, in attachment to allergens or other haptens, is capable of inducing an immunological tolerance in an individual of a mammalian species to the allergen or hapten. The allergen or hapten is attached to each of a plurality of the carboxyl groups of carboxymethyl cellulose. Tolerance has been induced in mice to three particular haptens, namely 2,4-dinitrophenyl, penicillin G and fluorescein in the specific embodiments of the present invention.

REFERENCES:
patent: 3794630 (1974-02-01), Mullan
patent: 3959080 (1976-05-01), Orth
Orth et al., Angew. Chem. Internat. Edit., vol. 11, No. 4, 1972, pp. 249-260.
Inman, J. of Immunol., vol. 114, 1975, pp. 704-709.
Howard & Courtenay, Eur J. Immunol., vol. 4, 1974, p. 603.

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