Method for treating glaucoma by the topical administration of se

Details Method for treating glaucoma by the topical administration of se Method for treating glaucoma by the topical administration of se

1981-06-23

1983-09-06

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424307, 424309, 560 66, 560 67, 560110, C07C 6976, A01N 3710, A61K 31235

Patent

active

044029748

ABSTRACT:
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower hydroxyalkyl, lower alkynyl, aralkyl, or an ester-containing group and Ar may be substituted or unsubstituted aromatic; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

REFERENCES:
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patent: 4127674 (0000-01-01), Leopold
patent: 4195085 (0000-01-01), Stone
Physicians' Desk Reference, Charles E. Baker, Jr., 35th Edition, 1232-1234 (1981).
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Heel et al., Drugs, 17 38-55 (1979).
Krieglstein et al., Albrecht v. Graefes Arch. klin. exp. Opthal., 202, 81-86 (1977).
P. Vareilles et al., Investigative Ophthalmology and Visual Science, vol. 16/11, 987 (1977).
T. Zimmerman, Drug Therapy, Jul. 1979, pp. 87-89.
T. J. Zimmerman and W. P. Boger, Surv. Ophthalmol.
Buechi, O. Melal, C. A., vol. 68 (1968) 76664u.

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