Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1998-08-21
2000-05-02
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
436829, 935 54, A61K 9133, A61K 9127
Patent
active
060569735
ABSTRACT:
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
REFERENCES:
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patent: 5620689 (1997-04-01), Allen et al.
patent: 5631018 (1997-05-01), Zalipsky
Kirpotin, D.B. et al., "Targeting of Liposomes to Solid Tumors: The Case of Sterically Stabilized Anti-HER2 Immunoliposomes," Journal of Liposome Research. 07(04): 391-417 (1997).
Park, J.W. et al., "Development of anti-p185.sup.HER2 Immunoliposomes for Cancer Therapy," Proc. Natl. Acad. Sci. USA. 92: 1327-1331 (1995).
Uster, P.S. et al., "Insertion of Poly(Ethylene Glycol) Derivatized Phospholipid into Pre-formed Liposomes Results in Prolonged in vivo Circulation Time," FEBS Letters. 386: 243-246 (1996).
Zalipsky, S. et al., "Poly(Ethlyene Glycol)-Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains," Bioconjugate Chem. 08: 111-118 (1997).
Allen Theresa M.
Martin Francis J.
Uster Paul
Zalipsky Samuel
Kishore Gollamudi S.
Mohr Judy M.
Sequus Pharmaceuticals, Inc.
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