Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1998-08-03
2000-05-02
Coggins, Wynn Wood
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604 93, A61M 100
Patent
active
060567252
ABSTRACT:
A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle through an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes. The catheter is part of a system for delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action to the hippocampus or lateral ventricle that includes a pump coupled to the catheter for delivering the indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action through the catheter to the hippocampus or lateral ventricle.
REFERENCES:
patent: 3894541 (1975-07-01), El-Shafei
patent: 3941119 (1976-03-01), Corrales
patent: 4613324 (1986-09-01), Ghajar
patent: 4670313 (1987-06-01), Saudagar
patent: 4686085 (1987-08-01), Osterholm
patent: 4710181 (1987-12-01), Fuqua
patent: 4767400 (1988-08-01), Miller et al.
patent: 4781672 (1988-11-01), Hooven
patent: 4998938 (1991-03-01), Ghajar et al.
patent: 5169387 (1992-12-01), Kronner
patent: 5180387 (1993-01-01), Ghajar et al.
patent: 5192753 (1993-03-01), McGeer et al.
patent: 5385541 (1995-01-01), Kirsch et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5405316 (1995-04-01), Magram
patent: 5468221 (1995-11-01), Schoner
patent: 5478807 (1995-12-01), Cronin et al.
patent: 5542935 (1996-08-01), Unger et al.
patent: 5552415 (1996-09-01), May
patent: 5643207 (1997-07-01), Rise
patent: 5683357 (1997-11-01), Magram
patent: 5728061 (1998-03-01), Ahmed
patent: 5756553 (1998-05-01), Iguchi et al.
patent: 5772261 (1998-06-01), Magram
patent: 5895378 (1999-04-01), Berensytein et al.
Dorland's Illustrated Medical Dictionary. W.B. Saunders Company 1985. p. 189.
Rich, et al., "Nonsteriodal Anti-Inflammatory Drugs in Alzheimer's Disease", Neurology, Jan. 1995, 45, p. 51-55.
Breitner, et al., "Inverse Association of Anti-Inflammatory Treatments and Alzheimer's Disease: Initial results of a co-twin control study," Neurology 1994: 44P.227-232.
Piet Eikelenboom, et al., "Inflammatory Mechanisms in Alzheimer's Disease", TiPs Dec. 1994 (vol. 15) p. 447-450.
Rogers, et al., "Clinical Trial of Indomethacin in Alzheimer's Disease", Neurology, Aug. 1993, pp. 1609-1611.
Meade, et al., "Differential Inhibition of Prostaglandin Endoperoxide Synthase (Cyclooxygenase) Isozymesn by Aspirin and Other Non-steroidal Anti-Inflammatory Drugs", The Journal of Biological Chemistry, Mar. 25, 1993, vol., 268 No. 9, p. 6610-6614.
Mitchell, Jane A., "Selectivity of Non-steriodal Anti-inflammatory Drugs as Inhibitors of Constitutive and Inducible Cyclooxygenase", Proceedings of the National Acadamy of Sciences, Dec. 15, 1993, vol. 90, No. 24, p. 11693-11697.
Malmberg, et al., "Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition", Science, vol. 257, Aug. 28, 1992, p. 1276-1279.
Forloni, et al., "Expression of Amyloid Precursor Protein mRNAs in Endothelial, Neuronal and Glial Cells: Modulation by Interleukin-1" Molecular Brain Research, 16 (1992), p. 128-134.
Michael Murphy, "The Molecular Pathogenesis of Alzheimer's Disease: Clinical Prospects" The Lancet, vol. 340:Dec. 19/26, 1992, p. 1512-1515.
Duong, et al., "Microtubule-Associated Proteins Ta and Amyloid P Component in Alzheimer's Disease", Brain Research, 603 (1993) p. 74-86.
Netland, et al., "Indomethacin Reverses .beta.-amyloid Induced Gliosis" Department of Psychiatry and Human Behavior, Miriam Hospital and Brown University Medical School, Providence, RI 02906.
Tate, et al., Continuous ICV Infusion of Synthetic .beta.-amyloid Peptide: Potential Model for Amyloid Deposition, Dept. of Psychiatry and Human Behavior, The Miriam Hospital, Providence, RI 02906.
Netland, Eric, "Neuropathological and Cognitive Impairment in an Animal Model of Alhzeimer's Disease" Bachelor of Science with Distinction in the Neuroscience Concentration thesis, Brown University, Apr. 21, 1995.
Soukas, Alexander, "Screening of a Possible Therapeutic Agent for Alzheimer's Disease" Biomedical Engineering Concentration of Brown University thesis, Apr. 28, 1995.
Meade, et al., "Differential Inhibition of Prostaglandin Endoreoxide Synthase (Cyclooxygenase) Isozymes by Aspirin and Other Non-steroidal Anti-Inflammatory Drugs", The Journal of Biological Chemistry, Mar. 25, 1993, vol., 268 No. 9 p. 6610-6614.
Rogers et al. "Clinical Trial of Indomethacin in Alzheimer's Disease", Neurology, Aug. 1993, pp. 1609-1611.
Coggins Wynn Wood
Kinghorn Curtis D.
Medtronic Inc.
Patton Harold R.
Sadula Jennifer R.
LandOfFree
Therapeutic method for treatment of alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutic method for treatment of alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic method for treatment of alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1590657