Tetrahydronaphthalene and indane derivatives

Details Tetrahydronaphthalene and indane derivatives Tetrahydronaphthalene and indane derivatives

1987-07-10

1989-10-24

Dixon, William R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546340, 546344, 546346, 546352, C07D21300

Patent

active

048763497

ABSTRACT:
The compounds of the formula ##STR1## wherein X and Y are independently --CH.sub.2 -- or >C(CH.sub.3).sub.2 ; Z is --CHR.sup.8 --, >Co, >CR.sup.8 OR.sup.7 , --CHR.sup.8 --CHR.sup.8 --, --CHOR.sup.7 --CH.sub.2 --, --CO--CHOR.sup.7 or --CHOR.sup.7 --CHOR.sup.7 --R.sup.1 is a 5- or 6-membered, monocyclic heterocyclic group which optionally can be C-substituted by halogen, lower-alkyl, lower-alkoxy, acyloxy, nitro, hydroxy, amino, lower-alkylamino or di-lower-alkylamino and/or which can be substituted on a ring --NH-- group by lower-alkyl; R.sup.2 and R.sup.3 are independently hydrogen, lower-alkyl, trifluoromethyl or halogen and one of R.sup.2 and R.sup.3 always is trifluoromethyl or lower-alkyl; R.sup.4 and R.sup.5 are independently hydrogen, alkyl, alkoxy or halogen; R.sup.6 is hydrogen, lower-alkyl or --OR.sup.7 ; R.sup.7 is hydrogen, lower-alkyl or acyl; R.sup.8 is hydrogen or lower-alkyl; and R.sup.7 and R.sup.8 can be the same or different from one another.

REFERENCES:
patent: 2427286 (1947-09-01), Knapp et al.
patent: 2512180 (1950-06-01), Smith
patent: 2558777 (1951-07-01), Papa et al.
patent: 3580909 (1971-05-01), Lehr
patent: 3679688 (1972-07-01), Fenton
patent: 3953434 (1976-04-01), Hauck et al.
patent: 4006240 (1977-02-01), Ho et al.
patent: 4284635 (1981-08-01), Zimmerman
patent: 4535086 (1985-08-01), Klaus et al.
patent: 4567184 (1986-01-01), Nusser et al.
patent: 4743606 (1988-05-01), Lazer
patent: 4757076 (1988-07-01), Hirsch et al.
J. Med. Chem. 1969, pp. 134-138.

Affiliated with

Also associated with

Rating

Tetrahydronaphthalene and indane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydronaphthalene and indane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydronaphthalene and indane derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1590154