Pyrazinoylguanidine and derivatives thereof having few polar sub

Details Pyrazinoylguanidine and derivatives thereof having few polar sub Pyrazinoylguanidine and derivatives thereof having few polar sub

1988-08-23

1990-08-28

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31495

Patent

active

049525824

ABSTRACT:
Hyperuretic agents of the formula: ##STR1## wherein Y is O or NH;

REFERENCES:
patent: 3313813 (1967-04-01), Cragoe
patent: 3345372 (1967-10-01), Hanifin
patent: 4196292 (1980-04-01), Woltersdorf
Kubo et al., CA 85:177484s.
The Journal of General Physiology, (1976), vol. 68, pp. 43-63, "Effect of Amiloride and Some of its Analogues on Cation Transport in Isolated Frog Skin and Thin Lipid Membranes", Dale J. Benos, et al.
"The Pharmacological Basis of Therapeutics", 7th Edition, Goodman & Gilman, pp. 901-903.
"Physician's Desk Reference", PDR 1987, 41st Edition, pp. 1319-1321.

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