Method and glycoprotein composition for inhibition of growth of

Details Method and glycoprotein composition for inhibition of growth of Method and glycoprotein composition for inhibition of growth of

1978-10-03

1981-04-14

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112B, 260112R, 424101, 424177, 435177, 435193, A61K 3512, A61K 3516, A61K 3702, C07G 700

Patent

active

042619769

ABSTRACT:
A glycoprotein which inhibits the growth of malignant cells or malignant tumors is obtained from animals and humans having malignant cells or tumors. The glycoprotein has a molecular weight of about 3600 and is a substrate for both the GT-I and GT-II isoenzymes of serum galactosyltransferase. The glycoprotein is isolated by subjecting a body fluid or extract of the malignant cells or tumors containing the protein to serial column separation steps with materials which concentrate glycoprotein and separate a fraction having a molecular weight of about 3600. The effective form of the glycoprotein as set forth herein is intended to include the glycoprotein as well as its physiologically and pharmacologically active metabolites in the body.

REFERENCES:
patent: 3607650 (1971-09-01), Maslianico et al.
patent: 3823126 (1974-07-01), Bjorklund
patent: 3928580 (1975-12-01), Fontaine
patent: 4042576 (1977-08-01), Eustache
Int. Arch. Allergy, vol. 36, pp. 191-203 (1969), Bjorklund.

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