Process for preparing 2',3'-dideoxy nucleoside derivatives

Details Process for preparing 2',3'-dideoxy nucleoside derivatives Process for preparing 2',3'-dideoxy nucleoside derivatives

1990-05-18

1992-04-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 24, 536 26, C07H 19473, C07H 19167

Patent

active

051069628

ABSTRACT:
A process for preparing 2',3'-didehydro-2',3'-dideoxynucleoside derivatives (III) ##STR1## by reacting a compound (I) ##STR2## with a viologen (N,N'-dialkyl-4,4'-bipyridinium salt) is disclosed. In the formulae R.sup.1 is C.sub.1-12 acyl or sulfonyl, R.sup.2 is hydrogen, C.sub.1-12 acyl, C.sub.1-12 alkyl, C.sub.6-18 aralkyl, or silyl, X is a halogen atom, and B is a purine, pyrimidine, imidazole, or triazole base residue.

REFERENCES:
patent: 3280104 (1966-10-01), Moffatt et al.
Kim-Thuan et al., Journal of Photochemistry, vol. 13, 257-259 (1980).
White et al., European J. Biochem., vol. 184, 89-96 (1989).

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